July 27, 2004



Lung Cancer Gene?

Researchers may have isolated (or may be close to isolating) the gene that determines susceptibility to lung cancer:

The Genetic Epidemiology of Lung Cancer Consortium (GELCC) examined 52 families who had at least three first-degree family members affected by lung, throat or laryngeal cancer. Of these 52 families, 36 had affected members in at least two generations. Using 392 known genetic markers, which are DNA sequences that are known to be common sites of genetic variation, the researchers generated and then compared the alleles (the different variations each gene can take) of all affected and non-affected family members who were willing to participate in the study.

First off, this is good news because it should provide some additional impetus for some people not to smoke. As the article explains:

Another interesting discovery the team made involved the effects of smoking on cancer risk for carriers and non-carriers of the predicted familial lung cancer gene. They found that in non-carriers, the more they smoked, the greater their risk of cancer. In carriers, on the other hand, any amount of smoking increased lung cancer risk. These findings suggest that smoking even a small amount can lead to cancer for individuals with inherited susceptibility.

Sure, many will argue that you would have to be crazy to smoke, anyway. Maybe the knowledge that you carry this gene would be enough to scare a long-time smoker into quitting; maybe not. But you would really have to be crazy to know that you carry this gene and go ahead and start smoking anyway.

Additionally, this news suggests a possible path to gene therapy treatments that could be used to prevent, maybe one day even cure, lung cancer. Great stuff.

Hat tip: M104 member and co-blogger Kathy Hanson

Posted by Phil at July 27, 2004 03:30 PM | TrackBack
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